What is alcoholic dementia: is it treatable?

Alcoholic dementia is brain damage that occurs as a result of long-term drinking of large amounts of alcohol. Clinically, this form of dementia is no different from others. Ethyl alcohol disrupts the functions of neurotransmitters that are responsible for human emotions and behavior. Long-term use of alcohol forms stable addiction and mental disorders. According to statistics, alcoholic dementia is most often diagnosed in men over 55 years of age. In the international classification of diseases ICD-10, alcoholic dementia is coded F10.6.

Doctors at the Yusupov Hospital diagnose and treat alcoholic dementia. Modern medical equipment that meets safety and quality requirements is used for the examination. Therapy is prescribed taking into account the individual characteristics of patients. Drugs are selected in accordance with European recommendations for the treatment of alcoholic dementia.

Causes of alcoholic dementia

Neuronal damage occurs due to prolonged exposure to aceldehyde. This is a substance formed during the breakdown of ethanol. Aceldehyde causes destruction of the vascular wall and provokes the formation of atherosclerosis. Chronic alcohol intoxication causes changes in brain structures, disruption of blood microcirculation and damage to the central nervous system. Men over 55 years of age are susceptible to dementia due to alcoholism. However, doctors do not rule out an earlier onset of the disease. Alcohol intoxication provokes the formation of the following causes leading to dementia:

• cerebrovascular accident;
• chronic cerebral ischemia;
• arterial hypertension;
• stenosis;
• atherosclerosis;
• Alzheimer's disease;
• Parkinson's disease;
• metabolic pathology.

The risk of developing alcoholic dementia increases with the presence of tumors, a history of head trauma, and a hereditary predisposition. Elimination of the etiological factor is necessary for complex treatment. If therapy is not started in time, alcoholic dementia can cause early disability.

Complications arising during treatment

After starting therapy, side effects occur that can lead the alcoholic to refuse therapy:

• withdrawal syndrome (the body’s reaction to the cessation of the effects of alcohol, which is manifested by severe pain and aches throughout the body);
• hangover seizures (a patient’s condition in which he loses consciousness, rolls his eyes, and body temperature rises);
• alcoholic delirium (manifestation of hallucinations, delirium, clouding of consciousness, deterioration of the patient’s mental and neurological condition, convulsions).

Important! In order for the patient not to stop treatment for alcoholic dementia, the doctor must eliminate the consequences of treatment: headache, drug intoxication, seizures, intestinal dysfunction.

Drugs are used that relieve neurological side effects (Lorazepam, Elenium). They prevent seizures and reduce the effects of withdrawal symptoms. They are used for a long time. The dose is selected so that the person is slightly drowsy.

Types of alcoholic dementia

Depending on the location of the lesion, the following types of alcoholic dementia are distinguished:

• Subcortical. Characterized by a narrowing of consciousness, fixation on imaginary problems. Patients are only concerned about themselves. Subcortical alcoholic dementia develops gradually. In the early stages, symptoms of depression and emotional lability appear. At the same time, memory is not impaired for a long time.
• Cortical. Accompanied by a more pronounced clinical picture and rapid progression. At the beginning of the disease, absent-mindedness and forgetfulness appear. As alcoholic dementia progresses, disorientation in time and space appears. Late stages are characterized by hallucinations.
• Multifocal. The clinical picture combines signs of subcortical and cortical lesions. The result is multifocal dementia. The patient's behavior becomes unpredictable, and complete personality degradation is observed. In the later stages of the disease, constant outside care is required.

The rate of progression of alcoholic dementia depends on the location of the pathological process. The destruction of neurons can quickly move to another zone with the formation of a multifocal lesion. If, against the background of alcohol dependence, there is an addiction to drugs, then the rate of progression of alcoholic dementia increases several times.

Expert opinion

Author: Vladimir Vladimirovich Zakharov

Neurologist, Doctor of Medical Sciences, Professor, Head of the Center for Diagnostics and Treatment of Memory Disorders

Alcoholic dementia is a gradual shutdown of brain function due to chronic intoxication with alcohol and metabolic products. Like any other type of dementia, it cannot be cured, but there is a chance to slow down its progression. And the sooner the patient turns to specialists, the better.

Dementia is characteristic of older age, but now we are faced with early manifestations of dementia. And one of the most significant reasons is alcohol. Unfortunately, in Russia there are no statistics on alcoholic dementia, because few people deal with such a problem. If you believe WHO data, then most often residents of the countries of the former USSR and some Asian countries, as well as Finland, suffer from dementia due to alcohol consumption.

The manifestations of all types of dementia are similar: personality degradation, memory loss, emotional lability, inability to care for oneself, and hallucinations. If the cause is alcohol, then patients are more aggressive. There is no need to think that dementia occurs with the last stage of alcoholism. With the constant use of “strong” drinks, many symptoms of the disease appear.

Damage to nervous tissue is irreversible, but modern drugs can slow down the degradation. Of course, you can’t do this with medications alone, and you need an integrated approach.

Explanations for the medical history

The patient developed a picture of diffuse dementia. In all likelihood, the immediate cause of the stroke was thrombosis of one of the branches of the middle cerebral artery. A high prothrombin index, observed soon after the onset of acute vascular syndrome, speaks in favor of thrombosis.

4 years after this, the prothrombin index also remains quite high. In addition, thrombosis is indicated by the slow development of the syndrome.

The interest of this type during the course of the disease lies in the fact that the resulting vascular syndrome cannot be explained by hypertension, atherosclerosis or enteritis - diseases not found in the patient and not characteristic of such a young age.

Consequently, the most likely cause of the catastrophic course of alcoholism in this case was the factor of chronic intoxication itself.

Stages of alcoholic dementia

Alcohol-induced dementia occurs in several stages. Among them are:

• Elementary. Clinical symptoms of damage to the central nervous system are not expressed. Depression gradually develops, detachment from other people, and withdrawal into oneself arise.
• Mild dementia. The toxic effects of aceldehyde lead to impaired memory and attention. As the lesion progresses, disorientation develops.
• Moderate dementia. Characterized by impaired mental activity and speech. At this stage, patients completely withdraw into themselves.
• Severe dementia. Total personality collapse. Patients do not recognize loved ones and do not orient themselves in time and space. The ability to self-service is completely lost.

Classification of the disease

It is worth noting that alcoholic dementia is not an independent disease, but a secondary disease that develops against the background of constant alcohol consumption. And it is classified according to three criteria - the degree of localization, the form of the disease and the degree of severity. According to the first type of classification, the disease can be subcortical, when subcortical formations are affected, and cortical, characterized by problems in the brain.

Depending on the severity of dementia, there are:

• light, characterized by slight forgetfulness and changes in some character traits.

  
  The patient may forget details of a conversation, become grouchy, and may have difficulty finding some words;

• moderate , in which the alcoholic may forget certain events and dates, and begins to navigate less well in space;
• heavy _ Characterized by severe memory disorders and personality disintegration. The person does not recognize close people - or even himself in the mirror, and has difficulty speaking and even eating on his own. At this stage, the patient cannot do without outside help.

The form of the disease can be lacunar or total. The first option is characterized by isolated lesions of brain structures. The patient is already beginning to forget some things, but can still compensate for memory loss by writing on paper. In total dementia, the frontal lobes are primarily affected, which leads to complete degradation. Concepts such as politeness and shame, delicacy and a sense of duty disappear.

Clinical picture of alcoholic dementia

Alcohol-induced dementia is characterized by gradual damage to neurons. The toxic effect of aceldehyde in the initial stages of the disease may be invisible to the patient himself, as well as to others. As the condition worsens, the following clinical symptoms appear:

• Memory impairment. Long-term memory is affected initially. The patient does not remember events or dates. Subsequently, short-term memory is impaired.
• Emotional lability. Alcohol addicts are characterized by emotional instability. In connection with the development of alcoholic dementia, aggression and infantilism appear. Patients can talk to themselves. Retardation appears. Actions become thoughtless.
• Depression. Often mistaken for chronic fatigue.
• Disorientation in time and space. Characteristic of late stages of alcoholic dementia. Patients do not understand where they are and cannot determine the time of day.
• Periods of enlightenment. Characteristic of the early stages of the disease. Another reason for enlightenment is the treatment performed.
• Dropping out of social life. As a result of alcoholic dementia, the patient becomes isolated on himself. The lives of those around him cease to concern him.
• Loss of professional skills. As nerve cell damage progresses, patients become unable to even perform self-care.
• Disturbance of the sleep-wake period. Bedtime may shift to morning or afternoon hours. Patients can sleep for several hours, while staying awake for several days in a row.
• Damage to the central nervous system. In this case, hand tremors, decreased muscle tone, slow reaction of the pupils to light, unsteady gait, and speech impairment appear. Such symptoms are considered a sign of irreversibility of the condition. The symptoms cannot be treated.

Diagnosis of alcoholic dementia

Diagnosis of alcoholic dementia requires a comprehensive approach. This form of dementia can be detected using an MRI or CT scan. Tomography allows you to establish the localization of the pathological process. Alcoholic dementia requires differential diagnosis with other brain lesions. The early stage of dementia is often mistaken for mental disorders, symptoms of tumor formation or intracranial hematomas.

The Yusupov Hospital uses modern medical equipment to detect the disease. Thanks to this, it is possible to detect neuronal damage even in the early stages. This allows for timely treatment and relieves the patient of pathological symptoms.

Forecast

If treatment began at an early stage, the prognosis is favorable, subject to absolute abstinence from alcohol and other addictions. If the patient develops obvious clinical symptoms of brain dysfunction, the consequences are not reversible. In this case, with the help of drug therapy, the process of destruction of neurons and cells of other organs is stopped.

When failure or death of internal organs occurs, the prognosis is unfavorable. The patient will require constant care.

If the function of the respiratory center of the brain is impaired, artificial ventilation is installed. On this device, vital functions are supported for a certain amount of time. Without treatment, such patients will die.

Treatment of alcoholic dementia

Alcohol-induced dementia is an irreversible condition. The main goals of therapy are to slow the progression of the disease and relieve symptoms. Treatment is selected depending on the stage of the disease.

• Easy. The initial stages of alcoholic dementia are treated with antidepressants and vitamin preparations. In addition, neurologists prescribe medications that normalize cerebral circulation and improve vascular function.
• Moderate. More severe clinical symptoms require extended therapy. For this purpose, drugs that relieve psychopathic symptoms are added to treatment.
• Heavy. Requires constant outside care. To alleviate the condition, sedatives and antipsychotic drugs are prescribed.

Treatment of alcoholic dementia is impossible without complete cessation of alcohol consumption. Drug therapy is complemented by dietary nutrition, psychotherapy, and physiotherapy. Doctors at the Yusupov Hospital pay special attention to concomitant diseases. Without stabilizing blood pressure readings and normalizing blood glucose levels, therapy will be considered ineffective. Due to the specifics of the condition, it is recommended that the first months of treatment be carried out in a hospital setting. At the Yusupov Hospital, an individual treatment plan is developed for each patient. Therapy is selected taking into account the stage of alcoholic dementia, the presence of concomitant diseases and the patient’s age. The drugs used are included in the list of European standards for the treatment of dementia due to alcoholism. All patients undergo consultation with a psychotherapist. This allows us to identify the causes of pathological addiction to alcohol. The method is most effective at the early stage of the disease.

What is the treatment for dementia?

The treatment program is developed individually for each patient. Specialized doctors are involved in working on it with the obligatory participation of narcologists, neurologists and psychiatrists. In this case, the general condition of the patient, his age, and the degree of disturbance of thought processes are taken into account. Typically, the plan of therapeutic measures includes taking medications that improve the patient’s condition - nootropics, neuroprotectors, antioxidants, calcium antagonists, etc. Replacement therapy, psychological support and specially developed methods for treating alcohol dependence are required.

Drug treatment should be accompanied in parallel by improving the patient’s living conditions, creating a comfortable psychological environment, treating concomitant diseases, eating a nutritious diet and maintaining good physical shape.

Forecast and prevention of alcoholic dementia

Most often, brain damage caused by alcoholism is an irreversible condition. A favorable prognosis is only possible if dementia is diagnosed in the early stages. Slow progression of the pathological condition leads to late seeking medical help. As neuronal damage progresses, the prognosis becomes poor. Severe stages of the disease require constant outside care and lead to disability.

Unlike other forms of dementia, alcoholic dementia is preventable. To do this, you must follow the following medical recommendations:

• lead a healthy lifestyle;
• adhere to the principles of rational and balanced nutrition;
• drink alcohol in moderation or completely abstain from it;
• timely treatment of somatic diseases.

Self-medication for alcoholic dementia is not possible. When the first signs of the disease appear, you should consult a doctor.

You can get diagnosed and treated for alcoholic dementia at the Yusupov Hospital. Experienced neurologists individually select therapy that meets international standards for the treatment of alcoholic dementia. You can make an appointment by phone.

What is the prognosis for alcoholic dementia?

If the disease is not treated professionally, the damage and death of neurons becomes irreversible. Indicators of social and household activity are significantly reduced. Sooner or later, a person stops working, begins to sell everything, including housing, becomes homeless and completely degrades as a person. As a result, there is a significant decrease in life expectancy - usually about 5 years pass from the onset of alcoholic dementia to death. With a rapidly developing course, this period is reduced to 1 year, or even six months.

With timely and adequate treatment, neurodegenerative processes can be stopped and a person can be returned to normal life. Therefore, it is so important for the patient’s loved ones to seek medical help in a timely manner. This should happen as soon as the first signs of cognitive decline are noticed. Without adequate treatment for alcoholism, it will be simply impossible to achieve normalization of vital functions.