Pramiracetam: effects, reviews, instructions for use.

Pramiracetam is a drug that can improve memory and overall cognition. Its unique properties make it a potentially powerful brain performance optimizer on its own or in a nootropic stack.

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Benefits and Effects of Pramiracetam

Pramiracetam is a true nootropic created specifically to improve cognition. Its benefits and effects include the following:

Improved memory

Pramiracetam is a proven memory enhancer that has been extensively tested for several decades. It has proven effective in both animal studies and clinical trials on young people with cognitive impairment due to brain injury.

Pramiracetam improves memory by stimulating the hippocampus, the part of the brain responsible for creating new memories. It is also effective in reducing forgetfulness. This dual action makes Pramiracetam a very effective memory enhancer. User reviews also report significant improvements in memory recall speed, which is supported by animal studies.

Increased attention and improved learning ability

Pramiracetam's reputation as a general cognitive enhancer has made it a popular choice among students.

Pramiracetam contributes to mechanisms underlying learning and memory by increasing neuronal nitric oxide synthase (NOS) activity in the hippocampus. NOS activity is associated with neural development and brain plasticity, which are critical for all aspects of cognition.

Pramiracetam is also known to increase the absorption of choline, thereby indirectly stimulating the production of acetylcholine. It is an important neurotransmitter that is closely associated with learning and cognition.

Dementia treatment

Open-label studies in patients with primary degenerative dementia show that pramiracetam is effective in reversing amnesia, significantly improving memory and reducing forgetfulness.

In other studies that measured the effects of pramiracetam and other racetam class nootropics in patients with mild to moderate dementia, results included cognitive and memory improvements. These results are believed to be due, at least in part, to the nootropics' potentiation of existing neurotransmitters.

Pramiracetam is commonly prescribed in Europe to treat dementia and other cognitive problems; associated with Alzheimer's disease and other neurological disorders.

"Social Freedom"

According to user reviews, it is known that pramiracetam makes them more creative in communication and socially free. This may be due, at least in part, to the supposed emotional blunting of pramiracetam. This effect may reduce social anxiety and, in turn, increase social freedom.

Neuroprotective capabilities

Pramiracetam is known to have significant neuroprotective effects that can improve cognitive function in people who have suffered traumatic brain injury.

It also has a pronounced neuroprotective effect when used during coronary artery bypass surgery, as well as in the treatment of cognitive disorders of cerebrovascular origin.

Pramycetam improves brain function

Pramiracetam extremely strongly activates a system called HACU - High Affinity Choline Uptake, a system of highly selective absorption of choline by neurons, which, with additional intake of choline sources, leads, firstly, to an improvement in the functional state of neuronal membranes, by increasing the synthesis of phospholipids, and secondly, to an increase in the concentration of acetylcholine in presynaptic neurons, and as a result of a stronger cholinergic response, due to a noticeable amount of released neurotransmitter, and thirdly, to increased neurogenesis of cholinergic neurons in the hippocampus, which subsequently leads to the disappearance of depression, improved thinking, memory, attention, control over one’s emotions and improved spatial perception.

How pramiracetam works

Like most nootropics, pramiracetam affects the release of neurotransmitters. Brain chemicals that transmit signals from one nerve cell to another. But pramiracetam does this in an indirect way, different from the normal action of racetam supplements, and also stimulates the brain in other ways.

Most racetams work by directly stimulating neurotransmitters, thereby increasing their production. But pramiracetam does not directly lead to changes in neurochemical levels. Its main direct effect is to significantly increase choline uptake in the hippocampus.

Choline is a precursor to acetylcholine. A neurotransmitter deeply involved in all cognitive processes, including learning speed, memory and concentration.

By stimulating the uptake of choline, pramiracetam indirectly modulates the release of acetylcholine and stimulates increased activity in the hippocampus. Because this part of the brain is important for memory function, the overall stimulation that pramiracetam provides can improve both the formation of new memories and the retention of referent or long-term memories. Increased activity in the hippocampus also increases cerebral blood flow, which increases attention and improves overall cognitive performance.

Pramiracetam may have other mechanisms of action. Researchers have hypothesized that in addition to its effects on the brain, pramiracetam acts in peripheral sites outside the brain that are dependent on the adrenal glands.

Animal studies suggest that pramiracetam may also increase or restore the fluidity of brain membranes, which facilitates cell signaling.

Unlike many other racetam class nootropics, pramiracetam does not appear to actively alter wakefulness or emotional states. This may be explained by the limited effect of pramiracetam on the production and release of neurotransmitters that have the greatest impact on mood and anxiety levels, such as serotonin, GABA and dopamine.

Pramiracetam is fat soluble, not water soluble, which means it is absorbed into the bloodstream through fatty acids. It reaches peak concentrations and maximum bioavailability relatively quickly, usually within 30 minutes, and has a moderately long half-life of 4.5-6.5 hours.

Instructions for use, dosage of pramiracetam

Existing human studies have used a total daily dose of 1200 mg of pramiracetam, divided into two or three doses per day.

This dosage is optimal, effective and well tolerated. It can be a good guide in determining dosage based on personal needs.

It is always advisable to start with the lowest possible effective dose and adjust the amount if necessary.

The fact that pramiracetam is fat-soluble and not water-soluble means that mixing the powder with water or any non-greasy liquid is difficult. Instead of dissolving, it will simply float on the surface. Some users report diluting their dose of pramiracetam powder with a small amount of oil. It may also improve absorption and bioavailability.

Many people prefer to take pramiracetam in capsule form because of its taste.

Combining Pramiracetam with Other Supplements

Pramiracetam works well on its own. But one of its most interesting aspects is that it is a powerful potentiator for other nootropics, increasing their effectiveness.

It is a particularly effective potentiator for other racetams, making it a natural addition to most nootropic stacks.

Adding choline to a pramiracetam stack may have several benefits. Not only can it enhance the effects of pramiracetam, but it can also prevent headaches, which is the most common side effect.

Since Pramiracetam has such powerful effects, it is advisable to use it on its own for a trial period before combining it with other nootropics.

Stack of Pramiracetam and Oxiracetam

Combining pramiracetam with an energy booster such as adrafinil or oxiracetam can enhance mental alertness and last longer.

1 per day

• Pramiracetam 300 mg
• 750 mg oxiracetam
• 300 mg CDP choline

Pramiracetam and Aniracetam

Combining pramiracetam with a powerful anti-anxiety drug like aniracetam can give users increased alertness, improving mood and reducing feelings of mental stress and restlessness. Reviews report that this stack promotes fluent communication and improves their public speaking ability.

1 per day

• Pramiracetam 300 mg
• 750 mg aniracetam
• 300 mg CDP choline

What can be replaced

Pramiracetam analogues have their own application features:

1. Piracetam was the first nootropic introduced into medical practice. Forms of application: tablets and injections. It prevents oxygen starvation of nerve cells, is used for excessive mental stress and in the complex treatment of withdrawal syndrome in alcoholism. For therapeutic purposes in Down syndrome, dyslexia, recovery from stroke. Do not use for stroke and renal failure.
2. Phenotropil is one of the best nootropic drugs. It is used to treat asthenic syndrome and has an anti-convulsant effect. It has a mild anorexigenic effect and is used in complex therapy for the treatment of obesity. Used as an analgesic for neuropathic pain. Improves vision and color perception. Can be used for varicose veins and thrombophlebitis, intoxication. Has no secondary effects.
3. Of all the nootropic drugs, Phenyl piracetam is included in the list of doping agents because it produces an amphetamine effect and also suppresses appetite. Increases efficiency, makes you want to sleep less. But doctors do not recommend taking it for more than three weeks.
4. Phenylpiracetam has similar properties to nootropics, but is 60 times more powerful than other supplements. It can be used by students and athletes, but it is tolerant, so you should not use it every day or for a long time.

Side effects of piracetam

Pramiracetam is generally well tolerated even in high doses, and very few side effects have been reported.

There are rare reports of minor and transient side effects. Including headache, gastrointestinal distress and feelings of nervousness or agitation.

In many cases, side effects are associated with high dosage and can be avoided by reducing the amount.

Choline depletion headache is a common side effect of racetams and can be prevented by taking pramiracetam in combination with supplemental choline.

Pramiracetam is not addictive and no significant side effects have been reported with long-term use. In fact, there is evidence that this supplement may even promote brain health and restore aging brain function to some extent.

Well

Pramiracetam, in general, is well tolerated; it has no serious contraindications, with the exception of increased sensitivity to the components of the drug and, traditionally, liver and kidney diseases.

Side effects have some similarities with piracetam. Irritability and drowsiness, allergies and agitation.

Headache is the most likely side effect. Which can be prevented. This has already been partially discussed in another issue; we will remind you how later.

The duration of taking pramiracetam is 2 months, a repeat course is also after 2 months. Dosage 1-1.5 grams/day. The half-life of pramiracetam is about 5 hours, and it is more advisable to take it 2 times a day, for example, in the morning and at lunch.

Take strictly with food or after meals, since the drug is 85.2% fat-soluble, this is the highest among racetams; piracetam, by the way, is 96.9% water-soluble.

Final Thoughts

Pramiracetam is a unique and powerful nootropic. Which has been shown to improve memory, improve overall cognition, and act as a neuroprotector.

Pramiracetam is prescribed in Europe for the treatment of dementia. In the US and Canada, it is most often used off-label as a nootropic.

Pros of pramiracetam include the fact that it is safe and generally well tolerated, with few side effects. It is powerful, fast-acting and relatively long-lasting. Effective on its own and with other compounds in nootropic stacks. Users typically report that it helps them study effectively and remember well, along with increased focus. Many users also say it increases their sense of social freedom.

The disadvantages of Pramiracetam include taste and price, which is usually higher than other racetam-type nootropics.

Overall, pramiracetam is considered a safe and effective nootropic. If you're interested in improving your memory, learning speed, and overall mental acuity, it might be worth considering.

Author: Evgeny Shevtsov

Pramiracetam. The aesthetic perception of the world has improved - as a result, tastes and interests have changed in many areas of life, a lot of thoughts have gained maturity, and the vector has been redirected.
The social circle has also changed, yes. Although in essence, it only improved, became more “quality”, closer to the ideal, deep, conceived from childhood by the ego of the individual. Only now, with the splitting of the ego, having broken the cup into small particles of emotions and feelings, I realized that I was not living according to the true source of joy, there was no trace of real peace of mind - now I understand why. Now it turns out that life is completely meaningless, so many years were wasted, and now - everything from the very beginning, from scratch. And is it possible to call this experience of revaluation of all values ​​a change in personality, because in vain I only threw off a hard shell, a shield from my personality, saturated with propaganda and hatred, and only returned to the roots? On the plateau I became acquainted with many, if not all, of the emotions inherent in our instincts, but unfortunately, it is very difficult to describe it verbally. I got the feeling from the course that, in addition to the new cumulative effect, an old psychological experience from the old course came to me. A double plateau, it turns out - a plateau within a plateau. It's a wonderful feeling to understand. One of the few factors that made our evolution possible, but so forgotten over the centuries... Perhaps that is why significant evolution does not occur in our time and that is the only reason why there are no superhumans in the world? After all, people's ignorance knows no bounds. Now that the Prama course is over, the effects are most pronounced: productivity is high, which was not there during, probably, the entire course. How wonderful it is to experience feelings. The same fear becomes multifaceted, envelops all thoughts and seems to seep into you, and for a while you already change and become diametrical as a person - one emotion - one transcendental experience. And yes, I’m cheating to some extent. I don’t see much point in talking about these sedimentary weeks, everything went smoothly - aniracetam had an effect on me, and I would even say I was able to reveal my potential, without pram: creativity, associative thinking, thoughts, freshness in the head - all this is an excellent boost for graphomania and communication in principle, because syntactic construction becomes easier and becomes more complex and multifaceted, he also began to use all sorts of aphorisms, without noticing it - although he previously did not like them. I write, carefully thinking about every word, trying to give the text meaning and feelings, sentimentality has appeared - by the way, I still don’t like it, but still... So - I’ll tell you about Pramiracetam! Pramiracetam - detailed review.

Pram ended, but many of the effects remained, some even intensified after such an abrupt cessation. I don’t feel much of a decline. Among the noticeable effects, deposited like small pieces in a puzzle, I notice that speech has changed. I speak in a completely different way: clearly, convincingly and beautifully. It's the same with writing. I write as competently as possible. Connecting words has become even faster, the process has been simplified to a minimum, and writing is a pleasure. Associative thinking has developed to an incredible level: thoughts are visualized into images, and they slip before the eyes in moments of time. Thoughts are remembered for a long time, so much so that the internal dialogue that takes place in the morning can be remembered and recalled verbatim a few days later. The last month has stretched out for a very long time, a lot of events and drastic changes have occurred. What remained of the pram was a pure consciousness and a fresh mind; objects and everyday things remained for me to look completely different. Most of the tricky questions simply disappeared for me, everything became clear on an intuitive level. The mind and subconscious mind do everything for me, questions like “Who am I”, “which road to choose”, “what is the best way to do it” no longer scare me, analytical thinking seems to have become more pluralistic, flexible, that I can look at one problem with absolute clarity. from different angles, I learned to find my own approach to each question, to change my view of the world and my personality, in fact, the strongest neuroplasticity - and in music, by the way, the same thing. A funny feature: when walking down the street, you see 3 screens at once - your face, a rear view and normal vision. It’s very funny to walk around with such simulated thoughts, from here facial expressions, gaze, articulation, gait, mood become completely 100% controllable, and this is not a fictitious experience - I often notice when communicating with people how easy it is to use it. Oh yes, and also aesthetics, damn aesthetics. The world is damn beautiful, it’s breathtaking to look at. The aesthetics of the world tear your eyes apart, music is listened to only of particularly high quality, memory works completely differently, the colors are clear, the sound is perfect, facial expressions and eloquence are at their apogee. At the peak of the effects, and from the post-effects of the pram, the head is still working more productively than usual, like a clock - every second is filled with something, and time seems to disappear into the rut of affairs and tasks. After all this, you stop procrastinating, you begin to engage not in introspection, but in action - life goals, knowledge in your favorite areas, improving skills, etc. And it’s very sad that such an insight came only now and only from the influence of the drug, and will everything that I’m writing about now disappear? Everything is possible. Time began to feel completely different, and this is a fact, I often associate myself with the hero of the film “The Butterfly Effect”, it’s a pity that I can’t control time - if I went back a few years ago, I would give my old noble kick in the ass.

A few more words about the pram.

-If you take precautions, then nothing will suffer from your psyche except your psyche. Under it, you feel like you’re in a panic attack, your former personality disappears, your ego splits into small pieces, thoughts fly at incredible speed - that you don’t have time to catch and comprehend them, only the pitiful shadows of these very mental jungles remain. The neural network becomes many times more plastic, therefore blows from the environment acquire phenomenal power, they will hit deeper than usual, however, after such an experience, the psyche and personality are so strongly tempered that it seems that that’s all - there is no further harm, you become ready to everything, you become tolerant of the opinions of others, stick to your line, become confident in yourself, turn off emotions and feelings - after all, cold rationalism is much more respectable. You become a perfectionist - no more entertainment, just work and work, and work must be completed to the very end, otherwise you will explode from the inside - you become wildly aggressive under such a “plateau” state, when the peak of the effects of pram begins to control you, your actions become extremely empirical - and extremely large-scale. Intention in business has developed. Under this onslaught of powerful thoughts, revision, you can significantly upend your former way of life, and how things turn out is pure fortune, to be honest. The weaker the personality, the worse. All possible childhood desires, complexes, shortcomings, mental illnesses spill out - onto you and the world around you. You feel like the world belongs to you. I want to turn everything around for myself, there were days without dreams, because under this state I could not bring myself to go to bed, you stop needing the support and approval of others, you turn into a wandering ascetic, not knowing fatigue and laziness, knowing only your destiny and life goal. Ambitions expand, the prism disappears, you begin to see the world in all its beauty - like a child. I want to do everything at once, learn everything, harness all the niches of art, immerse myself in the world of science and knowledge... It’s difficult to describe the maximum effects, especially at the layman level, but here’s what happened: Imagine the wild death agony on the physical level. At the peak of these frightening and all-consuming sensations, you begin to live here and now - in a word, you turn on. For my entire life. This condition is unique. YOU see everything and everyone, you see everything in advance, but you live only in this second, because who knows whether you will survive the next one. In this state, the meaning of existence disappears and is replaced by a surge of strength and motivation. But you can also compress the entire text into one word - inspiration. The real damn inspiration for everything! Pure inspiration. When you stop participating in the creation of thoughts, and transfer all processes to the brain, the “subconscious”, and in the end you take all the knowledge in transit, without prisms and an internal “filter”, even information that is not always understood, you transfer it without difficulty. Well, yes, awareness in this case gives me control over my emotions, and, as it were, allows me to immerse myself and see absolutely all the details in all their glory. Predictions of events and everything else, intuition. I don’t want to believe in inexplicable things and slide into schizoterism after such a sharp rise. I think a sophisticated intellect can predict many things. Pure creativity, no complexes or problems, no stupid thoughts - just me and my subconscious. Cool, isn't it? But in general, this is not its main effect - the main one is in thinking, the “turbo mode” of the brain, one might say - under it the head works 3-4 times faster than usual, sometimes the thought process accelerates to serious speed, that you stop understanding your same thoughts. You begin to despise yourself, and basically you hate everything around you, that’s in short. But you begin to despise yourself for real reasons, if there are any. If your psyche is strong, then nothing terrible can happen a priori, and you will only get a positive result from the course. His boost in thinking is comparable only to speed (which I have not tried and which are prohibited in the Russian Federation) (remember - if you try speed, you will die in a week). In general - very good. The course itself, for the most part, although unpleasant, is extremely effective. The results - from changes in everyday life to rethinking the values ​​and priorities of your old ones. I didn’t move the roof - that’s already good, so the impressions at the moment are only positive, I’ve been missing such a shake-up for a long time. In terms of nootropic effects, now I’m probably 3-4 times more productive than during the entire course. In the last weeks of the first week and the plateau itself, which for me characterizes only a cognitive explosion, I am unable to convey it in words - so I will leave this futile attempt, I just fought with myself, and it’s hard to call it anything other than an internal massacre . I was ready to kill myself in this state. -Immunity strengthened after the course. A strange nuance, I didn’t even want to push it here - but still: thermoregulation has improved, I go on some super frosty days without a hat, I can easily tolerate sub-zero temperatures, is this hardening or self-hypnosis? I haven’t been sick for six months, it’s incredible - if you knew me in real life, you would know how often and seriously I was sick - literally every few months. -Increased awareness, intuition, wit and sensitivity in communication - I wrote about all these effects more than once in a previous article (about my NRT-Combination) I will leave it here as a reference. -Perfectionism. This is the fourth effect of pram - in addition to sharpened thinking, improved memory, aggressiveness and high awareness. All matters require immediate intervention, and because I cannot leave my post without completing every detail, scrupulously and meticulously going through absolutely all options for solving problems, I did not go to bed. You can call it increased productivity. -Change in worldview. Everything you need to know about this is written above. That's all for now. Briefly and clearly. I hope I won’t leave you offended - after all, I put all my energy and soul into this article. With this I will say goodbye to you. Bye bye.