Anaprilin tablets: instructions for use, indications, price, reviews on forums and analogues

Pharmacodynamics and pharmacokinetics

The main active ingredient is propranolol . Anaprilin is a non-selective adrenergic blocker, reduces the sympathetic effect on beta-adrenergic receptors of the heart, reduces the frequency and strength of heart contractions, reduces the contractile function of the myocardium, regulates cardiac output downwards, blocks the positive inotropic and chronotropic effect of catecholamines, reduces the heart's need for oxygen, reduces arterial pressure. The mechanism of action of the drug is aimed at increasing bronchial tone through blockade of beta2-adrenergic receptors. Anaprilin increases the contractility of the uterus, reduces the risk of bleeding during childbirth, the postpartum and postoperative periods.

When taken orally, the drug is quickly absorbed and excreted from the body. The maximum peak content of the active substance in the blood plasma is recorded after 1 -1.5 hours. The drug penetrates the fetoplacental barrier.

Indications for use of Anaprilin tablets

What does the drug help with?

Indications for the use of Anaprilin are: arterial hypertension , sinus tachycardia , angina pectoris, supraventricular tachycardia, unstable angina, atrial fibrillation (tachysystolic form), prevention of migraine attacks, sympathoadrenal crises, NCD. For arterial hypertension, the drug is effective in the initial stages of the disease, and therefore is used more often in young people (under 40 years of age). A decrease in systolic pressure is accompanied by a decrease in heart rate, a decrease in cardiac output and stroke volume. For coronary heart disease, taking the drug reduces the number of angina and increases resistance to physical activity. Particularly effective for concomitant arterial hypertension and arrhythmias.

For what diseases is Anaprilin indicated?

The drug is prescribed in the following cases:

for chronic hypertension;
coronary heart disease, angina pectoris;
renal hypertension;
arrhythmias provoked by rheumatic lesions of the heart muscle: sinus, parochymal, atrial fibrillation, extrasystole;
as part of rehabilitation therapy: for myocardial infarction, intoxication with digitalis and other medications that disrupt the heart rhythm;
in the complex treatment of thyrotoxicosis;
with open-angle glaucoma;
with essential tremor;
for the prevention of migraines and cerebrovascular accidents.

With the exception of cases of poisoning with potent drugs, Anaprilin is recommended to be taken regularly. The therapeutic effect is achieved after the first dose and increases over time. By the end of the second week, a persistent hypotensive effect is observed.

Contraindications

Anaprilin is not prescribed for arterial hypotension , intolerance to components, heart failure, atrioventricular block, sinus bradycardia , sinoatrial block , diabetes mellitus, acute myocardial infarction, bronchial asthma, obliterating vascular diseases, metabolic acidosis , tendency to bronchospasm, vasomotor rhinitis , during pregnancy, breast nom breastfeeding

Side effects

Bradycardia , atrioventricular block, bronchiolospasm, the development of Raynaud's syndrome , heart failure, vomiting, muscle weakness , epigastric pain, vomiting, diarrhea , itching , depression , hypoglycemia - of diabetes are noted. diabetes , visual impairment, decreased potency.

Anaprilin tablets, instructions for use (Method and dosage)

The initial dosage of the drug for arterial hypertension is 40 mg, twice a day. No more than 320 mg per day.

For heart rhythm disturbances, angina pectoris: 20 mg three times a day with a gradual increase in dose to 120 mg in 2-3 doses.

How to take for migraine prevention and essential tremor? First, 20 mg of the drug is prescribed 2-3 times a day, then the dose can be increased to 160 mg.

According to the instructions for use of Anaprilin for pathology of the renal system, dosage adjustment is not required.

The drug Anaprilin - reviews

Tayra
https://otzovik.com/review_1314196.html

I have mixed opinions about this drug. I took it for the first time almost 13 years ago. Then it helped me a lot against tachycardia. I took the course for no more than 3 weeks. I did not observe any side effects.

The cardiologist prescribed me anaprilin again 2 years ago (more precisely, it was prescribed as a replacement for a drug that was no longer available in pharmacies). Without hesitation, I purchased and began taking it according to the regimen indicated by the doctor. As a result, I received a whole group of side effects. Namely, severe weakness, very low blood pressure (even though I took a small dose of the drug), fatigue. In general, I had to stop taking anaprilin ahead of schedule.

As for one-time help, as neurologists sometimes advise, I can’t say much - yes, it slows down the pulse, but it won’t solve the problem!

I won’t recommend it because I’m not happy with the side effects at all.

Mireya
https://otzovik.com/review_510788.html

I first tried anaprilin when the emergency doctor discovered that I had high blood pressure (120*90), (my normal blood pressure is 110*70). He gave me an anaprilin tablet and told me to put the tablet under my tongue. According to him, anaprilin acts faster this way.

What I would like to note is that yes... my blood pressure dropped to 90*60, but for me this is already too much... And what’s more, I burned the mucous membrane of my tongue with anaprilin, and the dry mouth did not go away for a long time. After one anaprilin tablet, I treated my tongue with olive oil for a week, since it did not want to obey me and was very painful. I had difficulty chewing food. The skin was peeling off the tongue...

Now I’ll think next time whether to take anaprilin or not. Thanks to bitter experience... Most likely I did something wrong when I took anaprilin, although it seemed like I was only following the doctor’s orders from the ambulance...

Milkiboy
https://otzovik.com/review_4515745.html

Greetings, dear readers, we all know about a drug called Anaprilin “every grandmother has them on hand”, but I will not talk about their direct purpose, but about the fact that with their help you can fight fear...

I myself am very shy, I often experience panic attacks, I had difficulty communicating with the opposite sex...

On the Internet, in search of a solution to my problem, I found a description of these tablets. Indeed, after taking it, I felt some relief and was not so afraid to communicate with people I didn’t know, panic attacks became significantly less

And so let's move on to the method of reception:

Place two tablets under your tongue and hold them until you feel slight weakness and an incomprehensible calmness; as soon as you feel this, spit out the remaining medication and rinse your mouth with water. “Do not swallow saliva or the tablets themselves.”

I also do not recommend abusing Anaprilin because this will lead to a worsening of the situation and also heart problems.

kotenych
https://irecommend.ru/content/pomogaet-ot-volneniya-v-slozhnykh-situatsiyakh-primenyat-s-ostorozhnostyu

Hi all.

I’ll say right away that I didn’t use Anaprilin for its intended purpose, since I don’t have any problems with my heart or blood pressure. But I had the opportunity to experience in practice its other properties, which not everyone knows about.

But first, a little theory (here please correct me if I make mistakes). Anaprilin is an adrenaline receptor blocker. In a stressful situation, this same adrenaline is released in the body in large quantities and begins to affect our body. This is where the physical reaction to stress comes from when it is strong enough: sweating, flushing, trembling hands, rapid heartbeat. Anaprilin blocks these receptors, and they become insensitive to adrenaline. That is, all (or many) physical symptoms disappear (or weaken), and you can behave adequately.

Therefore, Anaprilin can be used in situations such as interviews, public speaking, important exams, etc. Usually 40 mg is enough (but you should always try to get by with a smaller dose). If you don’t swallow it, but put it under your tongue, then 10-20 mg is enough.

I want to warn those who were delighted and ran to buy!

Anaprilin is a heart medicine, so it should be used with extreme caution. You can drink it as rarely as possible and only for a serious reason. Firstly, tolerance to it develops very quickly, meaning you will need to constantly increase the dose to get any effect. I highly do not recommend drinking more than 60-80 mg at a time! Secondly, if taken frequently, you can get serious heart problems. So, no more than a couple of times a month and no more than 40 mg at a time.

Nadezhda S

I couldn’t believe my eyes when 4 years ago I was prescribed Anaprilin to prevent migraines. It was recommended to me back in my senior year. Although we didn’t have the Unified State Exam then, we were no less worried. Since the middle of the year, I began to experience tachycardia when hearing the word “exam,” and in the end, looking at my redness and paleness, they sent me to the hospital. As a result, I took these pills for some time to normalize the nervous system itself with valerian in pills. Now I remember - that would be something to worry about. Graduated with 2 or 3 B's. Apparently, I have an excellent student complex, which I have almost overcome by now, resorting to therapy of common sense and not caring about what is happening :)

And so I was prescribed Anaprilin for migraines. At that time, I had a headache at least once a week, for three days. Sometimes it happened like this: 3rd headache, then 2nd it doesn’t hurt, and then it hurts again.

I drank them for a while but didn’t find any significant changes. There was still a positive change, which is why I give it 5 stars out of 10. The interval between headaches has increased to an average of 5-6 days. That is, the total number of attacks per month decreased, but the migraine itself also tormented me for three days, and the strength of these pains did not decrease.

After the next appointment, the doctor realized that this effect did not suit me or her, she canceled Anaprilin and allowed me to take sumatriptan drugs. They didn’t cause headaches any less often, but there was a real opportunity to relieve the pain for 12 hours.

Elena Lyubimova

Anaprilin was prescribed to me by a doctor several years ago. This medicine is very accessible and inexpensive. I had a slight heart rhythm disturbance, that is, signs of arrhythmia and migraine. The doctor who prescribed this drug was young and inexperienced, and at that time I didn’t particularly understand drugs.

After taking the first tablets, I felt bad and I began to study the instructions for using Anaprilin. In the end, I found the reason myself. The thing is that I always have low blood pressure, and Anaprilin also lowers it. That's why I felt bad. And the doctor who prescribed me the drug Anaprilin simply did not take this into account.

As far as I know, according to the stories of acquaintances and friends, Anaprilin is a good drug, it helps a lot in the treatment of arrhythmia and tachycardia, it just didn’t suit me at all. Before taking Anaprilin, you must carefully study the instructions and take into account contraindications so as not to end up in the same situation as me. It’s also good that I stopped taking this medication at the right time.

Galinka Malinka

I take anaprilin tablets very rarely in order to quickly lower my blood pressure. If you have high blood pressure, emergency doctors and your local physician recommend taking anaprilin.

Anaprilin acts faster if you put it under the tongue, but there is a chance of burning the mucous membrane under the tongue. I myself have encountered this problem, and therefore I put anaprilin tablets under my tongue and wash them down with a little water to further relieve dryness and burning in my mouth.

The price and cost of anaprilin tablets is affordable. You can buy anaprilin at a pharmacy without a prescription. Instructions for anaprilin are included with the tablets without fail.

Reviews about anaprilin tablets are different, so read and draw the appropriate conclusions for yourself...

For those who are not suitable for anaprilin, emergency doctors also advise taking capoten (captopril), capoten (captopril) tablets have a sour taste and do not cause such a burning sensation as anaprilin. The action of anaprilin and capoten is the same.

Be healthy and watch your blood pressure! Now you can measure your blood pressure for free in any pharmacy. After all, it is better to prevent a disease than to treat it for a long time and sometimes unsuccessfully...

Interaction

Anaprilin mutually enhances the negative effects of diltiazem and verpamil on the myocardium, inhibits the elimination of lidocaine, and prolongs the duration of action of non-polarizing muscle relaxants . The hypotensive effect is weakened when taken simultaneously with glucocorticosteroids , estrogens, and NSAIDs. The hypotensive effect is enhanced by the use of nitrates. Antacids and heparin reduce the concentration of the drug in the blood, phenothiazines and cimetidine increase it. Concomitant use with MAO inhibitors . Anaprilin increases the concentration of theophylline in plasma and slows down its metabolism.

Anaprilin

When used simultaneously with hypoglycemic agents, there is a risk of developing hypoglycemia due to the increased effect of hypoglycemic agents.

When used simultaneously with MAO inhibitors, there is a possibility of developing undesirable manifestations of drug interactions.

Cases of the development of severe bradycardia have been described when using propranolol for arrhythmia caused by digitalis drugs.

When used simultaneously with drugs for inhalation anesthesia, the risk of suppression of myocardial function and the development of arterial hypotension increases.

When used simultaneously with amiodarone, arterial hypotension, bradycardia, ventricular fibrillation, and asystole are possible.

When used simultaneously with verapamil, arterial hypotension, bradycardia, and dyspnea are possible. Cmax in the blood plasma increases, AUC increases, and the clearance of propranolol decreases due to inhibition of its metabolism in the liver under the influence of verapamil.

Propranolol does not affect the pharmacokinetics of verapamil.

A case of severe arterial hypotension and cardiac arrest has been described when used simultaneously with haloperidol.

When used simultaneously with hydralazine, the Cmax in the blood plasma and the AUC of propranolol increase. It is believed that hydralazine may reduce hepatic blood flow or inhibit the activity of liver enzymes, resulting in a slower metabolism of propranolol.

When used simultaneously, propranolol can inhibit the effects of glibenclamide, glyburide, chlorpropamide, tolbutamide, because Non-selective beta2-blockers are able to block pancreatic beta2-adrenergic receptors associated with insulin secretion.

The release of insulin from the pancreas due to the action of sulfonylurea derivatives is inhibited by beta-blockers, which to some extent prevents the development of the hypoglycemic effect.

When used simultaneously with diltiazem, the concentration of propranolol in the blood plasma increases due to inhibition of its metabolism under the influence of diltiazem. An additive depressant effect on cardiac function is observed due to the slowing of impulse conduction through the AV node caused by diltiazem. There is a risk of developing severe bradycardia, stroke and minute volume are significantly reduced.

With simultaneous use, cases of increased concentrations of warfarin and phenindione in the blood plasma have been described.

When used concomitantly with doxorubicin, experimental studies have shown increased cardiotoxicity.

When used simultaneously, propranolol prevents the development of the bronchodilator effect of isoprenaline, salbutamol, and terbutaline.

With simultaneous use, cases of increased concentrations of imipramine in the blood plasma have been described.

When used simultaneously with indomethacin, naproxen, piroxicam, acetylsalicylic acid, the antihypertensive effect of propranolol may be reduced.

When used simultaneously with ketanserin, an additive hypotensive effect may develop.

When used simultaneously with clonidine, the antihypertensive effect is enhanced.

In patients receiving propranolol, severe arterial hypertension may develop if clonidine is abruptly discontinued. It is believed that this is due to an increase in the content of catecholamines in the circulating blood and an increase in their vasoconstrictor effect.

When used simultaneously with caffeine, the effectiveness of propranolol may be reduced.

With simultaneous use, it is possible to enhance the effects of lidocaine and bupivacaine (including toxic ones), apparently due to a slowdown in the metabolism of local anesthetics in the liver.

When used simultaneously with lithium carbonate, a case of bradycardia has been described.

With simultaneous use, a case of increased side effects of maprotiline has been described, which is apparently due to a slowdown in its metabolism in the liver and accumulation in the body.

When used simultaneously with mefloquine, the QT interval increases, and a case of cardiac arrest has been described; with morphine - the inhibitory effect on the central nervous system caused by morphine is enhanced; with sodium amidotrizoate - cases of severe arterial hypotension have been described.

When used simultaneously with nisoldipine, an increase in the Cmax and AUC of propranolol and nisoldipine in the blood plasma is possible, which leads to severe arterial hypotension. There is a report of increased beta-blocking action.

Cases of increased Cmax and AUC of propranolol, arterial hypotension and a decrease in heart rate have been described when used simultaneously with nicardipine.

When used simultaneously with nifedipine in patients with coronary artery disease, severe arterial hypotension may develop, increasing the risk of heart failure and myocardial infarction, which may be due to an increase in the negative inotropic effect of nifedipine.

Patients receiving propranolol are at risk of developing severe hypotension after taking the first dose of prazosin.

When used simultaneously with prenylamine, the QT interval increases.

When used simultaneously with propafenone, the concentration of propranolol in the blood plasma increases and a toxic effect develops. Propafenone is believed to inhibit the hepatic metabolism of propranolol, reducing its clearance and increasing serum concentrations.

With the simultaneous use of reserpine and other antihypertensive drugs, the risk of developing arterial hypotension and bradycardia increases.

With simultaneous use, the Cmax and AUC of rizatriptan increases; with rifampicin - the concentration of propranolol in the blood plasma decreases; with suxamethonium chloride, tubocurarine chloride - the effect of muscle relaxants may change.

With simultaneous use, the clearance of theophylline decreases due to a slowdown in its metabolism in the liver. There is a risk of developing bronchospasm in patients with bronchial asthma or COPD. Beta blockers may block the inotropic effect of theophylline.

When used simultaneously with phenindione, cases of a slight increase in bleeding without changes in blood clotting parameters have been described.

When used concomitantly with flecainide, additive cardiodepressive effects are possible.

Fluoxetine inhibits the CYP2D6 isoenzyme, which leads to inhibition of the metabolism of propranolol and its accumulation and may enhance the cardiodepressive effect (including bradycardia). Fluoxetine and, mainly, its metabolites are characterized by a long T1/2, so the likelihood of drug interactions remains even several days after discontinuation of fluoxetine.

Quinidine inhibits the CYP2D6 isoenzyme, which leads to inhibition of the metabolism of propranolol, while its clearance decreases. Increased beta-blocking action and orthostatic hypotension are possible.

With simultaneous use in the blood plasma, the concentrations of propranolol, chlorpromazine, and thioridazine increase. A sharp decrease in blood pressure is possible.

Cimetidine inhibits the activity of microsomal liver enzymes (including the CYP2D6 isoenzyme), this leads to inhibition of the metabolism of propranolol and its cumulation: an increase in negative inotropic effect and the development of a cardiodepressive effect are observed.

With simultaneous use, the hypertensive effect of epinephrine is enhanced, and there is a risk of developing severe life-threatening hypertensive reactions and bradycardia. The bronchodilator effect of sympathomimetics (epinephrine, ephedrine) decreases.

With simultaneous use, cases of decreased effectiveness of ergotamine have been described.

There are reports of changes in the hemodynamic effects of propranolol when used simultaneously with ethanol.

special instructions

Taking the drug together with tranquilizers and antipsychotics . During long-term treatment with Anaprilin, it is recommended to simultaneously take cardiac glycosides . Discontinuation of the drug should be carried out gradually to prevent the development of acute myocardial ischemia or bronchospasm. For arrhythmias, the beta-blocker Anaprilin helps normalize sinus rhythm, transition atrial fibrillation from tachysystolic to bradysystolic and reduce subjective interruptions in the heart. Possible inhibition of reaction and attention, which must be taken into account when prescribing the drug to drivers, operators and people of similar professions.

Recipe in Latin: Rp.: Anaprilini 0.01 D. td N 20 in tabul. S.

Anaprilin price, where to buy

The price of Anaprilin tablets is 10 rubles per pack of 30 pieces of 40 mg.

You can buy a package of 50 pieces of 10 mg for 20 rubles.

Online pharmacies in RussiaRussia
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How to use Anaprilin: instructions

The treatment regimen depends on age, physical condition, type and severity of the disease. General recommendations:

Swallow the tablets without chewing with a sufficient amount of water;
time of administration: on an empty stomach: 20–30 minutes. before meals or 1.5 hours after.

For adults, the recommended initial daily dose is 40 mg: once or in doses of 10 mg. four times a day. If well tolerated, the dosage is increased by taking 40 mg. 2–3 times a day. Depending on the physical condition, the maximum dose of the drug is from 160 to 320 mg.

After a heart attack, therapy with Anaprilin begins in the period from 5 to 21 days:

the first 4 days take 40 mg. 3–4 times a day;
in the following days the regimen is changed: the single dosage is doubled: up to 80 mg. At the appointment, take the tablets twice a day.

In acute conditions: attacks of angina pectoris, arrhythmia, high intraocular or intracranial pressure, Anaprilin injections are indicated. Injections of the solution are given once or in short courses of 3–5 days.

For children with cardiovascular diseases, treatment with Anaprilin is allowed from 3 years of age according to individual indications. For them, the dosage is calculated according to body weight: 0.25–0.5 mg. per 1 kg. up to 3 times a day.

The duration of the course of oral administration is several months. If the condition changes, the treatment regimen is adjusted. Therapy is discontinued gradually to avoid potential withdrawal effects.