Citramon: side effects, instructions

"Citramon": composition and other characteristics

"Citramon" is an anesthetic that prevents inflammatory processes and also has an antipyretic effect. The only form of release is tablets. They are packaged in cardboard packages, each containing 10 or 6 pieces.

The active ingredient is acetylsalicylic acid (240 mg per tablet). The following are used as auxiliary components:

• citric acid (20 mg);
• phenacetin (180 mg);
• caffeine (20 mg).

The composition and dosage of components may vary significantly, as determined by manufacturers. The features of the tablet may also differ. For example, “Citramon Ultra”, unlike the classic “Citramon”, is a drug with film-coated tablets. This makes oral administration easier.

The effect on the body is complex:

1. Acetylsalicylic acid reduces temperature and resists inflammatory processes.
2. Caffeine stimulates excitation processes in the central nervous system and activates the brain.
3. In combination with acetylsalicylic acid and paracetamol, the drug has a pronounced analgesic effect.

The product is available freely and does not require a prescription. Stored at normal room temperature up to 25 degrees. The shelf life is 2 years from the date of production.

For reference

One of the common types of the drug is Citramon P. Along with the main components, it contains paracetamol, which enhances the analgesic and antipyretic effect.

Face masks made from menstrual blood: harmful or beneficial (and why?)

It seems like you can make a face mask out of just about anything these days: there are even magnetic masks or masks with snail mucus. But what about period blood (not to be confused with the “vampire lift” made popular by Kim Kardashian)? A few months ago, Gabrielle Schlegel posted a video of herself making a mask from her own secretions. Some netizens called this procedure disgusting and strange. Others found it inspiring - in particular, it helps overcome the stigma of menstruation. We decided to ask experts whether such unusual masks are beneficial for the skin.

When 22-year-old artist Gabrielle Schlegel first started menstruating, she perceived it as a curse. But after a while I decided that these were new opportunities for creativity. The girl began to draw pictures with her menstrual blood and apply the excess to her face as a mask.

Seeing myself in the mirror with blood smeared all over my face made me realize that there is absolutely nothing disgusting or wrong about period blood,” she says.

Gabriel Schlegel

Gabrielle Schlegel is sure that such close contact with her own secretions helped her come to terms with her own body and stop hating the cycle.

A picture painted in blood

In addition, the artist claims that the blood works wonders on her skin. If anything, Gabrielle now views her period as an opportunity to treat herself to a monthly spa session—free and made with all-natural ingredients.

A picture painted in blood

Not only does it make my skin glow, but the blood actively helps in treating acne, since it contains stem cells and many nutrients that were supposed to help raise a healthy child during pregnancy, she explains.

She even started sharing photos of her "bloody" masks on Instagram in an attempt to help others overcome period shame.

Many are ashamed and embarrassed simply because they were taught this. We are constantly encouraged to keep secret one of the most natural processes - the giving of life. “It’s not by nature,” Metro quotes the girl.

Many girls followed the artist’s example.

I learned that my blood is actually good for my skin (celebrities do "vampire lifts" and menstrual blood is even more nourishing), says one netizen.

Another girl claims that masks made from menstrual blood helped her get rid of eczema on her face.

At first it was scary to look in the mirror, but I decided to experiment and leave the “menstrual mask” on for about 30 minutes. After I washed the blood off with warm water, I was amazed. First of all, my face glowed like never before. While most masks irritate the skin and make it dry, this time the skin was hydrated and glowing, and the wrinkles around the eyes completely disappeared. “I literally felt like a new person,” the girl shares her impressions.

Expert opinion

Arguments for:

Menstrual blood is the liquid discharge from the vagina during menstruation. Strictly speaking, the more correct term is menstrual fluid, since its composition, in addition to blood itself, includes the mucous secretion of the cervical glands, the secretion of the vaginal glands and endometrial tissue, experts explain.

Menstrual blood (compared to “normal”) contains significantly more arsenic, phosphorus, sodium, calcium (50 times more), minerals, chlorine, and less magnesium, radon, and iodine. Thus, in its physical properties, content of organic and inorganic substances, menstrual blood differs significantly from peripheral (“normal”) blood.

Menstrual blood is rich in stem cells. Contrary to popular belief, menstrual blood is not a waste product equivalent to urine, for example.

In our modern world, menstrual blood is often considered dirty, unclean, or useless. However, for thousands of years throughout the world, menstrual blood was considered healing, rubbed into the skin and believed to heal wounds. In the Philippines, locals still wash their faces with their first menstrual blood, arguing that this ritual will make their face clean and free of acne.

According to an article in CBS News, researchers at Medistem have discovered that under the right conditions, menstrual stem cells, now known as regenerative endometrial cells, can develop into different types of tissue. Moreover, they do it much faster.

According to Marina Miusova, head of the anti-age department at Lazerjazz, such a mask can indeed have a lifting effect, but this happens due to the protein content in the blood.

This effect can occur from any blood, venous, and even from protein.

All useful components - calcium, magnesium and other elements are not absorbed through the skin. True, the content of enzymes in the blood together with protein can give a slight lightening effect. There will be no harm from such a mask. However, the process itself is unnatural and can cause dizziness due to the smell of blood during such a procedure, says a cosmetologist and dermatologist.

The expert adds that there are specialized products and procedures that contain enzymes and vitamin complexes that are purified and prepared for absorption by the skin. For example, plasma therapy from your own blood enriched with vitamins.

Arguments against:

Actually, menstrual blood cannot harm the skin in any way. But the benefits of using “menstrual masks” have not been proven. Can menstrual blood improve the appearance of skin? This remains to be seen.

While the research results seem exciting, experts are skeptical about the trend. In any case, there is no actual scientific evidence or research to prove that menstrual blood masks are beneficial for the skin. View in full: https://www.spletnik.ru/beauty/beautyexpert/93579-polezny-li-maski-iz-menstrualnoy-krovi-dlya-kozhi.html

What do Citramon tablets help with?

The main purpose of the drug is to relieve moderate and mild pain in the presence of concomitant diseases:

• ARVI;
• flu;
• general malaise;
• febrile syndrome;
• neuralgia;
• arthralgia;
• algodysmenorrhea;
• migraine;
• myalgia;

The drug is used to treat headaches, muscle pain, dental pain, and joint pain. "Citramon" is effective in relieving any pain that is associated with inflammatory processes. It contains several active components that mutually enhance each other's actions.

Contraindications for use

Restrictions associated with the use of the product contain a fairly large list of disorders and diseases:

• nasal polyposis;
• bronchial asthma;
• hypersensitivity to one or more components;
• bleeding of the gastrointestinal tract;
• diathesis of hemorrhagic type;
• erosion, ulcer of the gastrointestinal tract (in the acute stage);
• portal hypertension"
• severe course of coronary heart disease;
• hemophilia;
• renal failure;
• increased nervous excitability;
• kidney failure;
• sleep problems;
• bleeding during operations;
• severe hypertension;
• glaucoma;
• simultaneous use of anticoagulant drugs;
• aortic aneurysm;
• pregnancy period (especially during the 1st and 3rd trimesters);
• feeding period (any stage);
• children up to 15 years old inclusive.

There are also relative contraindications in which Citramon should be taken with caution. These are liver dysfunctions, as well as gout.

Citramon P

Are common

This medicine should not be taken at the same time as medicines containing ASA or paracetamol.

As with other migraine treatments, caution should be exercised to rule out other potentially serious neurological disorders before initiating treatment for suspected migraine in patients who have not previously been diagnosed with migraine or in those whose migraine presents with atypical symptoms.

If patients vomit during >20% of migraine attacks or require bed rest during >50% of migraine attacks, the drug should not be used.

If the migraine does not stop after taking the first two tablets of the drug, you should seek medical help.

The drug should not be used if the patient has had more than 10 headache attacks per month for at least the last three months. In this case, headache due to excessive use of drugs should be suspected and treatment should be discontinued. Additionally, patients should seek medical attention. Caution should be used in patients with risk factors for dehydration, such as vomiting, diarrhea, or before or after major surgery.

Due to its pharmacodynamic properties, the drug can. mask signs and symptoms of infection.

Due to the content of acetylsalicylic acid in the drug

The drug should be used with caution in patients with gout, impaired renal or hepatic function, dehydration, uncontrolled hypertension, glucose-6-phosphate dehydrogenase deficiency and diabetes mellitus.

Due to ASA inhibition of platelet aggregation, the drug may lead to an increase in bleeding time during and after surgical interventions (including minor ones, such as tooth extraction).

The drug should not be used simultaneously with anticoagulants and other drugs that interfere with blood clotting, without medical supervision (see section “Interaction with other drugs”). Patients with bleeding disorders should be closely monitored. Caution should be exercised in case of metro- or menorrhagia.

If a patient develops bleeding or ulceration of the gastrointestinal tract while taking the drug, it must be discontinued immediately. Potentially fatal bleeding, ulceration, and perforation of the gastrointestinal tract may occur at any time during treatment with any NSAID, with or without a history of precursors and severe gastrointestinal complications. These complications tend to be more severe in older patients.

Alcohol, corticosteroids and NSAIDs may increase the risk of gastrointestinal bleeding (see section "Interaction with other drugs").

The drug may contribute to the development of bronchospasm and the occurrence of exacerbation of bronchial asthma (including bronchial asthma caused by intolerance to analgesics) or other hypersensitivity reactions. Risk factors include bronchial asthma, seasonal allergic rhinitis, nasal polyposis, chronic obstructive pulmonary disease, chronic respiratory tract infections (especially those associated with symptoms characteristic of allergic rhinitis). Such effects may also occur in patients with allergic reactions (eg, skin reactions, including itching and urticaria) to other substances. Particular caution is recommended in such patients.

Children under 18 years of age should not be prescribed medications containing acetylsalicylic acid as an antipyretic, since in the case of a viral infection they can increase the risk of Reye's syndrome. Symptoms of Reye's syndrome are hyperpyrexia, prolonged vomiting, metabolic acidosis, nervous system and mental disorders, hepatomegaly and liver dysfunction, acute encephalopathy, respiratory failure, convulsions, coma.

ASA may distort the results of laboratory tests of thyroid function due to false-positive low concentrations of levothyroxine (T4) and triiodothyronine (T3) (see section "Interaction with other drugs").

Due to the content of paracetamol in the preparation

Caution should be exercised when prescribing the drug to patients with impaired renal or hepatic function or alcohol dependence.

The risk of paracetamol poisoning is increased in patients taking other potentially hepatotoxic drugs or drugs that induce liver microsomal enzymes (eg, rifampicin, isoniazid, chloramphenicol, hypnotics and anticonvulsants including phenobarbital, phenytoin and carbamazepine).

Patients with a history of alcoholism are at particular risk for liver damage (see section “Interaction with other drugs”).

When using the drug, serious skin reactions may develop, such as acute generalized exanthematous pustulosis, Stevens-Johnson syndrome, toxic epidermal necrolysis, which can be fatal. Patients should be informed of the signs of serious skin reactions. The drug should be discontinued at the first manifestation of skin reactions or any other signs of hypersensitivity.

Due to the caffeine content of the product

The drug should be prescribed with caution to patients with gout, hyperthyroidism and arrhythmia.

When using the drug, you should limit your consumption of products containing caffeine, since excess caffeine intake can lead to nervousness, irritability, insomnia and, in some cases, increased heart rate.

Side effects

In case of overdose, long-term use, chronic diseases, as well as individual intolerance to the components, side effects are possible:

• anorexia;
• nausea;
• bleeding of the gastrointestinal tract;
• the appearance of ulcers on the mucous membranes of the gastrointestinal tract;
• liver failure;
• hypersensitivity;
• nephrotic syndrome;
• kidney failure;
• anemia;
• fatty hepatosis in acute form;
• complications associated with heart failure;
• sleep disorders, insomnia;
• headaches;
• tinnitus;
• dizziness;
• increased anxiety;
• heart rhythm disturbances;
• high blood pressure;
• psychological dependence (only in case of long-term use of high doses).

Cases of overdose

In small quantities, an overdose leads to ringing in the ears, nausea, vomiting, dizziness, and pale skin. In case of severe overdose, more serious disorders are observed:

• breathing problems;
• circulatory disorders;
• increased anxiety;
• feeling dazed;
• headache;
• nausea;
• bleeding;
• sweating;
• fatigue, increased drowsiness;
• convulsions;
• extremely rarely - coma.

In these cases, you must immediately stop taking the drug and its analogues with the same active ingredients. If the symptoms are severe, you will need to seek emergency medical help.

Instructions for use CITRAMONUM-BORIMED

Symptoms.

Symptoms of paracetamol overdose. Liver damage is possible in adults who took 10 g or more of paracetamol, and in children who took the drug more than 150 mg/kg body weight. In the first 24 hours:

• pallor, nausea, vomiting, anorexia and headache, hepatonecrosis, increased activity of “liver” transaminases, increased prothrombin index. Liver damage may appear 12-48 hours after taking excess doses of the drug. Impaired glucose metabolism and metabolic acidosis may occur. In severe poisoning, liver failure can lead to encephalopathy, coma and death. Acute renal failure with acute tubular necrosis can develop even in the absence of severe kidney damage. Cardiac arrhythmia was also noted. With long-term use of high doses, aplastic anemia, thrombocytopenia, pancytopenia, agranulocytosis, neutropenia, leukopenia are possible.

Symptoms of caffeine overdose. Large doses of caffeine can cause pain in the epigastric region, vomiting, diuresis, rapid breathing, extrasystole, tachycardia or cardiac arrhythmia, and affect the central nervous system (dizziness, insomnia, nervous agitation, irritability, state of passion, anxiety, tremor, convulsions).

Symptoms of an overdose of acetylsalicylic acid. In case of an overdose of salicylates, chronic intoxication resulting from long-term therapy is possible (use of the drug more than 100 mg/kg/day for more than 2 days can lead to toxic effects), as well as acute intoxication, the causes of which may be accidental use by children or an unintentional overdose.

Chronic poisoning with salicylates can be hidden, since its symptoms are nonspecific. Moderate chronic intoxication caused by salicylates occurs, as a rule, only after repeated doses of large doses.

Symptoms Impaired balance, dizziness, ringing in the ears, deafness, increased sweating, nausea and vomiting, headache, confusion. These symptoms can be controlled by reducing the dose. Tinnitus can occur when the concentration of salicylates in the blood plasma is more than 150-300 mcg/ml. Serious adverse reactions occur when the concentration of salicylates in the blood plasma is more than 300 mcg/ml. Acute intoxication is indicated by a pronounced change in the acid-base balance, which may differ depending on the age and severity of intoxication. The severity of the condition cannot be determined solely on the basis of the concentration of salicylates in the blood plasma.

Treatment:

discontinuation of the drug, gastric lavage with activated charcoal and administration of saline laxatives (magnesium sulfate) to prevent absorption of the drug in the stomach and intestines. Introduction of alkalizing agents to maintain urine pH values ​​at 7.5-8.0. When the level of salicylates in plasma exceeds 300 mg/l (2.2 mmol/l) in children and 500 mg/l (3.6 mmol/l) in adults, forced alkaline diuresis is indicated (provided by intravenous infusion of sodium bicarbonate 88 mEq/l and 5% glucose at a rate of 10-15 ml/kg/h with furosemide 40-60 mg). The volume of circulating blood is restored and the acid-base state is corrected. In case of cerebral edema, artificial ventilation of the lungs with an oxygen-enriched mixture in positive end-expiratory pressure mode is indicated. For cerebral edema, hyperventilation is performed in combination with the administration of osmotic diuretics.

In the presence of liver damage, a specific antidote of paracetamol, N-acetylcysteine, is administered. A 20% solution of N-acetylcysteine ​​is used intravenously and orally:

• first dose 140 mg/kg (0.7 ml/kg), then 70 mg/kg (0.35 ml/kg). A total of 17 doses are administered. The most effective treatment is started in the first 10 hours after the development of intoxication. If more than 36 hours have passed since intoxication, treatment is ineffective.

If the prothrombin index increases by more than 1.5, vitamin K1 (phytomenadione) 1-10 mg is used; if the prothrombin index increases to more than 3.0, it is necessary to begin infusion of native plasma or a concentrate of coagulation factors (1-2 units).

When treating intoxication, hemodialysis is contraindicated. It is unacceptable to use antihistamines and glucocorticosteroids. It is not recommended to use acetazolamide to alkalinize urine in the treatment of intoxication due to the possibility of developing acidemia and increasing the toxic effect of salicylate on the patient's body.